image: Oligomeric proanthocyanidin reduced H2O2-induced apoptosis in retinal ganglion cell line RGC-5 (Hoechst 33342 staining). The left: H2O2 (400 μM) group; the right: and H2O2 (400 μM) + oligomeric proanthocyanidin (20 μM) group. The arrowheads pointed to apoptotic cells. view more
Credit: <i>Neural Regeneration Research</i>
The death of retinal ganglion cells is a hallmark of many optic neurodegenerative diseases such as glaucoma and retinopathy. Oxidative stress is one of the major reasons to cause the cell death. A latest study, published in the Neural Regeneration Research (Vol. 8, No. 25, 2013), has shown that grape seed extract can protect retinal ganglion cells against oxidative stress-induced apoptosis. In this study, Prof. Kwok-Fai So, an academician of Chinese Academy of Sciences, and Prof. Daxiang Lu from Jinan University, China show that oligomeric proanthocyanidin, enriched in grape seeds, has a protective effect on retinal ganglion cells against oxidative stress-induced injury, as confirmed by using both RGC-5 cell lines and retinal explant culture. These findings imply a potential application of oligomeric proanthocyanidin in the clinical treatment of many neural diseases, from glaucoma, ischemia to neurodegenerative disease.
Article: " Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis," by Hui Wang1, 2, Chanjuan Zhang1, 2, Dan Lu1, 2, Xiaoming Shu1, Lihong Zhu1, 2, Renbing Qi1, Kwok-Fai So2, Daxiang Lu1, Ying Xu2 (1 Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of China, Jinan University School of Medicine, Guangzhou 510632, Guangdong Province, China; 2 GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, Guangdong Province, China)
Wang H, Zhang CJ, Lu D, Shu XM, Zhu LH, Qi RB, So KF, Lu DX, Xu Y. Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis. Neural Regen Res. 2013;8(25):2317-2326.
Contact:
Meng Zhao
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Neural Regeneration Research
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Journal
Neural Regeneration Research