Interleukin-18 promoter gene polymorphisms may be associated with ischemic stroke pathogenesis, and the –607C allele increases ischemic stroke risk in the Han Chinese population. The frequency distribution of genetic polymorphisms varies among different populations, races, and living environments. A recent study by Haiping Wang and colleagues from Qingdao University Medical College demonstrates that the –13T/C (rs11024595) polymorphism, in the 5′-flanking region of the serum amyloid A gene, shows no correlation with ischemic cerebrovascular disease. However, the C allele of the –607C/A (rs1946518) polymorphism in the interleukin-18 gene promoter is a strong risk factor for ischemic cerebrovascular disease in the Han population of northern China. In addition, the A allele is likely protective for ischemic cerebrovascular disease. These findings published in the Neural Regeneration Research (Vol. 8, No. 20, 2013) are considered to identify molecular genetic mechanisms involved in cerebrovascular disease pathogenesis.
Article: " Ischemic stroke susceptibility gene in a Northern Han Chinese population," by Haiping Wang1, Shujuan Shi2, Wenjing Yan1, Yan Song3, Jingjing Zhan4, Chen Zhang1, Haiji Wang3 (1 Department of Neurology, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China; 2 Health Care Office, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China; 3 Department of Gerontology, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China; 4 Department of Internal Medicine Ward 1, Jiao Nan People's Hospital, Jiaonan 266400, Shandong Province, China)
Wang HP, Shi SJ, Yan WJ, Song Y, Zhan JJ, Zhang C, Wang HJ. Ischemic stroke susceptibility gene in a Northern Han Chinese population. Neural Regen Res. 2013;8(20):1881-1891.
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Journal
Neural Regeneration Research