image: EGb761 improved the proliferation of neural stem cells in the subependymal zone of vascular dementia rats (immunofluorescence staining). The presence of green particles in the nucleus was the marker of BrdU-positive cells. BrdU: 5-Bromo-2-deoxyuridine. view more
Credit: <i>Neural Regeneration Research</i>
Neural stem cells proliferate in the subventricular zone and hippocampal dentate gyrus of adult mammals. However, the number of endogenous neural stem cells is insufficient to prevent cerebral ischemia/reperfusion injuries such as vascular dementia, so it is important to stimulate endogenous neural stem cell proliferation and differentiation. The ginkgo biloba extract EGb761 effectively and safely treats memory loss and cognitive impairments in patients with senile dementia. Prof. Yuliang Wang and team from Weifang Medical University observed the effects of EGb761 on proliferation of neural stem cells in the subventricular zone and dentate gyrus of rats with vascular dementia. Researchers found that the ginkgo biloba extract EGb761 promoted and prolonged the proliferation of neural stem cells in the subventricular zone and dentate gyrus of rats with vascular dementia. The cells continued to proliferate at 4 months. EGb761 also significantly improved learning and memory in rats with vascular dementia. These findings which were published in the Neural Regeneration Research (Vol. 8, No. 18, 2013) provide a new idea and approach to further explore the induced proliferation of neural stem cells in situ in the treatment of vascular dementia.
Article: " A ginkgo biloba extract promotes proliferation of endogenous neural stem cells in vascular dementia rats " by Jiwei Wang2, Wen Chen1, Yuliang Wang1 (1 Department of Physiology, Weifang Medical University, Weifang 261042, Shandong Province, China; 2 School of Medicine, Shandong University, Jinan 250012, Shandong Province, China).
Wang JW, Chen W, Wang YL. A ginkgo biloba extract promotes proliferation of endogenous neural stem cells in vascular dementia rats. Neural Regen Res. 2013;8(18):1655-1662.
Contact: Meng Zhao
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Journal
Neural Regeneration Research