RI Hospital: Use of PMP may increase demand for drug treatment, reduce painkiller abuse

PROVIDENCE, R.I. – A Rhode Island Hospital researcher has found that the use of electronic prescription drug monitoring programs (PMPs) may have a significant impact on the demand for drug treatment programs and how prescribers detect and respond to abuse of painkillers. The study by Traci C. Green, Ph.D., MSc, research scientist in Rhode Island Hospital's department of general internal medicine, is published online in advance of print in the journal Pain Medicine.

The study surveyed 1,385 providers in Rhode Island and Connecticut on their use of state PMPs, and found that PMP use was greater in Connecticut where an electronic PMP is available. PMPs are used to gather information about a patient's prescription history, and have the ability to verify patients' self-reported prescription history of abusable medications, aid in the determination of filling multiple prescriptions of the same drug from multiple providers, and assist in the cataloging of medications that may suggest contra-indications or increased risk of adverse events, like overdose.

Both states have reported significant increases in opioid-related death; in fact, overdose has surpassed motor vehicle crashes as the leading cause of unintentional injury death. A national survey indicates that Rhode Island has the highest per capita illicit drug use and ranks third, behind Oklahoma and Oregon, for non-medical use of prescription opioids among persons age 12 or older.

"Prescription drug monitoring programs have historically been oriented to criminal and judicial end users," Green said. "Use of PMPs by prescribers is growing, but how clinicians in actual practice use the data that these systems contain is not well understood."

The researchers surveyed providers in both states who are licensed to prescribe Schedule II medications. These medications have a high potential for abuse, which may lead to severe psychological or physical dependence. Schedule II medications include morphine, Dilaudid, Demerol, oxycodone, fentanyl, and methamphetamine, among others.

The study found that prescribers' use of an electronic PMPs may influence medical care and decisions, especially with opioid abuse detection, and is associated with clinical responses to suspected doctor shopping or diversion. Doctor shopping refers to patients who seek to obtain multiple prescriptions for abusable medications from multiple doctors.

When prescribers suspected a patient of doctor shopping or diverting medications, PMP users were more likely to ramp up clinical monitoring with urine drug screens or refer the patient to drug treatment. PMP users were also less likely to ignore the warning signs or to call law enforcement.

"One thing is clear," Green said, "Clinicians, not law enforcement, have the medical and behavioral health care expertise to guide patients struggling with addiction to get the help they need, when they are ready for it. PMPs can be an important clinical tool to address possible addiction issues and start that conversation."

Green added, "Our study suggests that if states want wider use of PMPs by their prescribers, we need to increase access to drug treatment, especially opioid-dependence treatment options, if we are going to make headway on the epidemic of painkiller abuse and overdose death in our communities."

Since the mid 1990s, there has been a significant nationwide increase in fatal overdose and opioid-related emergency department visits and hospitalizations, driven by a substantial growth in opioid analgesic prescriptions and non-medical use of prescription opioids. Most states report that just 25 percent of their prescribers are using PMPs, and few states require prescribers to check PMPs before dispensing medication.

"PMPs raise the red flags we could be missing on our own," Green said. "They call attention to multiple prescriptions by different doctors, and note contra-indications that put the patient at risk for injury or death. But not enough prescribers are using them. We need to further educate clinicians about these programs, improve drug treatment options and access, and make electronic PMPs more readily available so that this tool can be used most effectively to prevent unnecessary medication-related injury and death."

The study was supported by a research grant from the Centers for Disease Control and Prevention. Green's principal affiliation is Rhode Island Hospital, a member hospital of the Lifespan health system in Rhode Island. She also has an academic appointment at The Warren Alpert Medical School of Brown University. The research is fully supported by Rhode Island Hospital and the Lifespan health system. Other Lifespan researchers involved in the study are Peter D. Friedmann, M.D.; Marita Mann; Sarah Bowman; Nickolas Zaller, Ph.D.; as well as Xaviel Soto and John Gadea of the Connecticut Department of Consumer Protection; and Catherine Cordy and Patrick Kelly of the Board of Pharmacy at the Rhode Island Department of Health.

Founded in 1863, Rhode Island Hospital in Providence, R.I., is a private, not-for-profit hospital and is the principal teaching hospital of The Warren Alpert Medical School of Brown University. A major trauma center for southeastern New England, the hospital is dedicated to being on the cutting edge of medicine and research. Last year, Rhode Island Hospital received more than $55 million in external research funding. It is also home to Hasbro Children's Hospital, the state's only facility dedicated to pediatric care. For more information on Rhode Island Hospital, visit www.rhodeislandhospital.org, follow us on Twitter @RIHospital or like us on Facebook www.facebook.com/rhodeislandhospitalpage.