Almost a year's treatment with a vitamin D compound did not alleviate key structural and functional cardiovascular abnormalities in patients with kidney disease and cardiac enlargement. In a paper in the February 15 Journal of the American Medical Association, an international research team reports that daily doses of a vitamin D compound did not reduce enlargement or improve impaired functioning of the heart's main pumping chamber.
"Several studies have suggested that vitamin D therapy may improve cardiovascular health, so we were surprised that the results did not support our hypothesis that paricalcitol, which we use to treat hyperparathyroidsm in kidney disease patients, would reduce left ventricular hypertrophy and improve diastolic function in these patients," says Ravi Thadhani, MD, MPH, of the Massachusetts General Hospital Division of Nephrology, lead author of the JAMA report. "There was some evidence that paricalcitol may reduce the incidence of heart failure, but that will need to be followed up in a larger trial focused on that potential outcome."
Patients with chronic kidney disease become deficient in vitamin D, which leads to elevated parathyroid hormone (PTH) levels, commonly treated with paricalcitol. Since kidney disease patients are at increased risk of cardiovascular disease, which may be associated with vitamin D deficiency, the current study was designed to investigate the impact of paricalcitol treatment on specific cardiovascular abnormalities.
The PRIMO (Paricalcitol capsule benefits in Renal-failure-Induced MOrbidity) study enrolled 227 participants from 60 centers in 11 countries, all of whom had chronic kidney disease and mild to moderate enlargement of the left ventricle. Participants – whose PTH levels had just reached the point where paricalcitol could be prescribed – were randomly assigned to receive daily doses of either paricalcitol or a placebo for 48 weeks. Changes in the size of the left ventricle were measured by cardiac MRI, and ventricular function was assessed by echocardiography and MRI.
At the end of the study period, participants receiving paricalcitol did have lower PTH levels, but there was no significant difference between the two groups in either left ventricular enlargement or in echocardiographic measures of ventricular function. Fewer members of the paricalcitol group were hospitalized for cardiovascular disease, and those participants also had lower blood levels of a biomarker for heart failure; but the study was not large enough to confirm a reduced risk of heart failure with paricalcitol treatment.
"The study did not support our hypothesis but presented us with two intriguing findings," says Scott Solomon, MD, director of Noninvasive Cardiology at Brigham and Women's Hospital and senior author of the JAMA report. "If the larger outcomes studies that are currently underway confirm a paricalcitol benefit in heart failure, our results suggest that the mechanism must be something other than reducing left ventricular hypertrophy or improving diastolic function."
Solomon is a professor of Medicine and Thadhani an associate professor of Medicine at Harvard Medical School. Additional study co-authors include Yuchiao Chang, PhD, Julia Wenger, MPH, Hector Tamez, MD, MPH, and Ishir Bhan, MD, MPH, Massachusetts General Hospital; Amil Shah, MD, and Ajay Pachika, MD, Brigham and Women's Hospital; and Evan Applebaum, MD, and Warren Manning, MD, Beth Israel Deaconess Hospital. The study was supported by Abbott Laboratories, which markets paricalcitol under the brand name Zemplar.
Brigham and Women's Hospital (http://www.brighamandwomens.org) is an international leader in basic, clinical and translational research on human diseases, involving more than 900 physician-investigators and renowned biomedical scientists and faculty supported by more than $537 million in funding. BWH is also home to major landmark epidemiologic population studies, including the Nurses' and Physicians' Health Studies and the Women's Health Initiative.
Massachusetts General Hospital (http://www.massgeneral.org), founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of more than $750 million and major research centers in AIDS, cardiovascular research, cancer, computational and integrative biology, cutaneous biology, human genetics, medical imaging, neurodegenerative disorders, regenerative medicine, reproductive biology, systems biology, transplantation biology and photomedicine.
Journal
JAMA