DENVER — Using a novel aptamer-based proteomics array technology, researchers and collaborators have identified biomarkers and protein signatures that are hallmarks of cancer at an early stage for two of the most aggressive and deadly forms of cancer — pancreatic and mesothelioma.
This technology would enable better clinical diagnosis at an earlier stage and may provide insight into new therapeutic targets, said Rachel Ostroff, Ph.D., clinical research director of Somalogic Inc.
"Currently these cancers are detected at an advanced stage, where the possibility of cure is minimal," said Ostroff. "Detection of these aggressive cancers at an earlier stage would identify patients for early treatment, which may improve their survival and quality of life."
Ostroff presented results of this ongoing study at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development.
Discovered about 20 years ago, aptamers are nucleic acid molecules that bind to specific proteins. SomaLogic has developed the next generation of aptamers, SOMAmers (Slow Off-rate Modified Aptamers), which have superior affinity and specificity. SOMAmers enable a highly multiplexed proteomic platform used for simultaneous identification and quantification of target proteins in complex biological samples.
The goal of this study was to determine if this proteomics technology could identify blood-based biomarkers for pancreatic cancer or mesothelioma in people diagnosed, but not yet treated, for cancer.
Participants in the control group had symptoms that resembled these cancers, but were benign (i.e. pancreatitis or lung fibrosis).
Ostroff and colleagues tested blood from participants to discover the biomarkers specific to those with cancer, which would then be used to identify these diseases at an early stage, where the potential for effective treatment is much higher than in disease that has progressed.
For both forms of cancer, the researchers discovered biomarkers and developed a signature with high accuracy for detection of each form of cancer. Equally important, they found high specificity, meaning few people without disease will be incorrectly diagnosed and thus avoid unnecessary tests or treatments.
"Validation studies are underway, which we hope will lead to the development of diagnostic tests that hold clinical benefits for patients," Ostroff said.
Pancreatic cancer is the fourth leading cause of cancer-related death in the United States. Mesothelioma is an asbestos-related pulmonary cancer that causes an estimated 15,000 to 20,000 deaths per year worldwide.
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The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, the AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. The membership includes 32,000 basic, translational and clinical researchers; health care professionals; and cancer survivors and advocates in the United States and more than 90 other countries. The AACR marshals the full spectrum of expertise from the cancer community to accelerate progress in the prevention, diagnosis and treatment of cancer through high-quality scientific and educational programs. It funds innovative, meritorious research grants, research fellowships and career development awards. The AACR Annual Meeting attracts more than 18,000 participants who share the latest discoveries and developments in the field. Special Conferences throughout the year present novel data across a wide variety of topics in cancer research, treatment and patient care. The AACR publishes six major peer-reviewed journals: Cancer Research; Clinical Cancer Research; Molecular Cancer Therapeutics; Molecular Cancer Research; Cancer Epidemiology, Biomarkers & Prevention; and Cancer Prevention Research. The AACR also publishes CR, a magazine for cancer survivors and their families, patient advocates, physicians and scientists, providing a forum for sharing essential, evidence-based information and perspectives on progress in cancer research, survivorship and advocacy.