Selenoprotein P Exerts Its Effects upon Binding to LRP1 Receptor of Muscles, Inducing Exercise Resis (IMAGE)

Kanazawa University

Selenoprotein P Exerts Its Effects upon Binding to LRP1 Receptor of Muscles, Inducing Exercise Resis

Caption

In patients with type-2 diabetes and in those with fatty liver, overproduced selenoprotein P exerts its effects on muscles through its binding to LRP1 receptor. Selenoprotein P incorporated into muscles induces antioxidant proteins such as GPX1 and SeW, As the result, the level of reactive oxygen produced by physical exercise is suppressed, and those patients suffer from pathology of 'exercise resistance' due to low responsiveness to physical exercise.

Credit

KANAZAWA UNIVERSITY

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